2-Aminophenol → HCID 68604368, compound

HRID 1948805Notes

Reaction equation

HRID 1948805 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=O.[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[OH:16]>C(O)C.C(O)(=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:9]=[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]1[OH:16]

Participants

5

Reactant 2

HCID 58012-Aminophenol2×HCID 142732-Pyridinecarboxaldehyde2×

Product 1

HCID 68604368HCID 68604368, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 702EthanolSolvent

Procedure

200 μl (2 mmol) of 2-pyridinecarboxaldehyde (reagent 1) and 220 mg (2 mmol) of 2-aminophenol (reagent 2) were dissolved in 10 mL of dry ethanol. One drop of glacial acetic acid was added and the reaction mixture was stirred during 12 h. The solution was filtered on paper and the filtrate was evaporated to dryness. After a chromatography on silica gel (CH2Cl2, 100 ml then AcOEt 200 ml), 394 mg of ligand L1 were obtained as orange solid with a yield of 100%.

Workup

  1. filtrationThe solution was filtered on paper
  2. customthe filtrate was evaporated to dryness
  3. customwere obtained as orange solid with a yield of 100%

Sources & evidence

ORD record
ord-306682bcff584cddad66d7ef2f9127d0
Source dataset
uspto-grants-2013_03
Patent number
US08399582B2

Reaction notes

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