反应详情

温度

70 °C

To a suspension of 5-acetyl-2-(2,4-dichloro-phenyl)-1H-pyrrole-3-carbonitrile (6.2 g, 22.21 mmol) in 155 mL of toluene was added N,N-dimethylformamide diisopropyl acetal (18.6 mL; 88.85 mmol). The mixture was allowed to stir for 34 hours at 70° C. Then, a further amount of reagent was added (4.6 mL; 22.21 mmol) and the mixture was heated to 80° C. for additional 18 hours under efficient stirring.

1. additionThen, a further amount of reagent was added (4.6 mL; 22.21 mmol)
2. temperaturethe mixture was heated to 80° C. for additional 18 hours under efficient stirring