N,N,N-trimethyl-1,1-bis(1-methylethoxy)amine → 2-(2,4-Dichloro-phenyl)-5-((e)-3-dimethylamino-acryloyl)-1h-pyrrole-3-carbonitrile

Participants

Reaction Conditions

Reaction Steps

To a suspension of 5-acetyl-2-(2,4-dichloro-phenyl)-1H-pyrrole-3-carbonitrile (6.2 g, 22.21 mmol) in 155 mL of toluene was added N,N-dimethylformamide diisopropyl acetal (18.6 mL; 88.85 mmol). The mixture was allowed to stir for 34 hours at 70° C. Then, a further amount of reagent was added (4.6 mL; 22.21 mmol) and the mixture was heated to 80° C. for additional 18 hours under efficient stirring.

Provenance & Evidence