3-Bromopyridine → HCID 68574980, compound

HRID 1949005Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:22]=[CH:21][CH:20]=[CH:19][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH:17]=[CH2:18])[CH:13]=2)[N:8]=1.Br[C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1>>[CH3:1][O:2][C:3]1[CH:22]=[CH:21][CH:20]=[CH:19][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12](/[CH:17]=[CH:18]/[C:24]3[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=3)[CH:13]=2)[N:8]=1

Participants

Reactant 2

HCID 122863-Bromopyridine

HCID 68574383HCID 68574383, compound

Product 1

HCID 68574980HCID 68574980, compound

Procedure

(2-Methoxy-benzyl)-(6-vinyl-quinolin-2-yl)-amine (240 mg, 0.828 mmol) was reacted with 3-bromopyridine (170 mg, 1.08 mmol) as described in example 2 step B. The title compound was obtained as a yellow waxy solid (100 mg, 33%), MS: m/e=368.0 (M+H+).

Sources & evidence

ORD record: ord-eb11914ebbf2476c925e06ea4b4d9374
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399674B2

Reaction notes

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