Dichloromethane → 4-(aminomethyl)-N-[1-(4-chlorophenyl)ethyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

HRID 194904Notes

Reaction equation

HRID 194904 reaction equation
[Cl:44][CH2:45][Cl:46].[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH:15]([CH3:16])[NH:17][C:18](=[O:19])[C:20]2([CH2:35][NH:36][C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:21][CH2:22][N:23]([c:26]3[c:27]4[c:28]([n:29][cH:30][n:31]3)[nH:32][cH:33][cH:34]4)[CH2:24][CH2:25]2)[cH:13][cH:14]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH:15]([CH3:16])[NH:17][C:18](=[O:19])[C:20]2([CH2:35][NH2:36])[CH2:21][CH2:22][N:23]([c:26]3[c:27]4[c:28]([n:29][cH:30][n:31]3)[nH:32][cH:33][cH:34]4)[CH2:24][CH2:25]2)[cH:13][cH:14]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 91184969tert-butyl N-[[4-[1-(4-chlorophenyl)ethylcarbamoyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methyl]carbamate

Product 1

HCID 666733214-(aminomethyl)-N-[1-(4-chlorophenyl)ethyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

Sources & evidence

ORD record
ord-d8a3988fc9ba486187577f6babee098f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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