HCID 50913954, compound → HCID 58129390, compound

HRID 1949071Notes

Reaction equation

HRID 1949071 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2([OH:26])[CH2:18][CH2:17][N:16](CC3C=CC=CC=3)[CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>C(O)C.C(O)(=O)C.[Pd]>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11]([C:13]2([OH:26])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[O:12])=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 1

HCID 50913954HCID 50913954, compound

Product 1

HCID 58129390HCID 58129390, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 702EthanolSolvent

Procedure

A mixture of 33 mg (0.09 mmol) 1-benzyl-4-hydroxy-piperidine-4-carboxylic acid (4-isopropyl-phenyl)-amide in 15 mL ethanol and 10 uL acetic acid was hydrogenated over Pd/C with 1 bar H2 for 2 h at room temperature. The mixture was filtered, the catalyst washed with ethanol and the filtrate evaporated to dryness yielding 33 mg (70% purity) of the title compound. MS (m/e): 263.1 [(M+H)+].

Workup

  1. filtrationThe mixture was filtered
  2. washthe catalyst washed with ethanol
  3. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-5dc9977dc2b548baa958a5ef8fa16d65
Source dataset
uspto-grants-2013_03
Patent number
US08399676B2

Reaction notes

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