反应详情

4.3 g (14.4 mmol) 2-hydroxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester (precursor VVV05) were heated together with 13.3 ml (144.1 mmol) POCl3 for 2 h at 100° C. After cooling to RT the mixture was concentrated to small volume under vacuum. 4.5 g (14.2 mmol, 98%) 2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester were obtained as residue.

1. concentrationwas concentrated to small volume under vacuum