Hydrochloric Acid → HCID 58277416, compound

Participants

Reaction Steps

0.21 g (0.526 mmol) of the compound of Example 38A are provided in 3.5 ml of methanol and, at room temperature, 295 mg (5.26 mmol) of potassium hydroxide are added. The mixture is heated under reflux for 5 min, a 1N aqueous hydrogen chloride solution is subsequently added until the pH is 5, and the resulting precipitate is collected by suction filtration, washed with diethyl ether and dried under high vacuum. 145 mg (82% of theory) of the title compound are obtained.

Provenance & Evidence