Hydrochloric Acid → HCID 58277416, compound

HRID 1949245Notes

Reaction equation

HRID 1949245 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=3[F:20])=[CH:11][C:10]([C:21]([O:23]CC)=[O:22])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[OH-].[K+].Cl>CO>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=3[F:20])=[CH:11][C:10]([C:21]([OH:23])=[O:22])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 58277273HCID 58277273, compound

Product 1

HCID 58277416HCID 58277416, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.21 g (0.526 mmol) of the compound of Example 38A are provided in 3.5 ml of methanol and, at room temperature, 295 mg (5.26 mmol) of potassium hydroxide are added. The mixture is heated under reflux for 5 min, a 1N aqueous hydrogen chloride solution is subsequently added until the pH is 5, and the resulting precipitate is collected by suction filtration, washed with diethyl ether and dried under high vacuum. 145 mg (82% of theory) of the title compound are obtained.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 5 min
  3. filtrationthe resulting precipitate is collected by suction filtration
  4. washwashed with diethyl ether
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-688fccc78c104080a75f579b3d31f863
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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