Acetonitrile--water (1/1) → HCID 58277330, compound

HRID 1949273Notes

Reaction equation

HRID 1949273 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:14]=3)=[CH:11][C:10]([C:24]([O:26]CC)=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F.C(#N)C.O>C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:14]=3)=[CH:11][C:10]([C:24]([OH:26])=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 18373917Acetonitrile--water (1/1)HCID 58277295HCID 58277295, compoundHCID 58277326HCID 58277326, compound

Product 1

HCID 58277330HCID 58277330, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 69A in analogy to the synthesis of the compound of Example 71A and with purification by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with the addition of 0.1% formic acid). 46 mg (100% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-e6165780e3334aa8816aba2d1793a346
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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