Azetidine → HCID 67153455, compound

HRID 1949311Notes

Reaction equation

HRID 1949311 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]2[N:20]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=3)[N:19]=[C:18]([C:28]([N:30]3[CH2:34][C:33](=[O:35])[NH:32][CH2:31]3)=[O:29])[CH:17]=2)[CH:11]=1)(=O)=O.[NH:36]1[CH2:39][CH2:38][CH2:37]1.[CH:40]([OH:42])=[O:41].ClC1C=C(N2C(C3C=CC=C(OCCCN(C)C)C=3)=CC(C(N3CC(=O)NC3)=O)=N2)C=CC=1>O1CCCC1>[CH:40]([OH:42])=[O:41].[N:36]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([C:16]3[N:20]([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=4)[N:19]=[C:18]([C:28]([N:30]4[CH2:34][C:33](=[O:35])[NH:32][CH2:31]4)=[O:29])[CH:17]=3)[CH:13]=[CH:14][CH:15]=2)[CH2:39][CH2:38][CH2:37]1

Participants

5

Reactant 3

HCID 10422AzetidineHCID 58277334HCID 58277334, compoundHCID 67153505HCID 67153505, compound

Product 1

HCID 67153455HCID 67153455, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 120A and azetidine without the addition of tetrahydrofuran in analogy to the synthesis of the compound of Example 29. 13 mg (11% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-224083dc4eac4685bf534b1cca4f0831
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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