Morpholine → HCID 67153308, compound

HRID 1949315Notes

Reaction equation

HRID 1949315 reaction equation
CS(OC[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=3)[N:18]=[C:17]([C:27]([N:29]3[CH2:33][C:32](=[O:34])[NH:31][CH2:30]3)=[O:28])[CH:16]=2)[CH:10]=1)(=O)=O.N1CCOCC1.[CH:41]([OH:43])=[O:42].ClC1C=C(N2C(C3C=CC=C(OCCCN(C)C)C=3)=C[C:53]([C:69]([N:71]3[CH2:75][C:74](=[O:76])N[CH2:72]3)=O)=N2)C=CC=1>O1CCCC1>[CH:41]([OH:43])=[O:42].[Cl:26][C:22]1[CH:21]=[C:20]([N:19]2[C:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:7][CH2:72][N:71]4[CH2:69][CH2:53][O:76][CH2:74][CH2:75]4)[CH:10]=3)=[CH:16][C:17]([C:27]([N:29]3[CH2:33][C:32](=[O:34])[NH:31][CH2:30]3)=[O:28])=[N:18]2)[CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 58277451HCID 58277451, compoundHCID 67153505HCID 67153505, compound

Product 1

HCID 67153308HCID 67153308, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 121A and morpholine without the addition of tetrahydrofuran in analogy to the synthesis of the compound of Example 29. 47 mg (43% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-3c2cf3d7bd684ad7a5e1ffd6f1d93cda
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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