Diisopropylethylamine → HCID 44230321, compound

HRID 1949320Notes

Reaction equation

HRID 1949320 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([F:21])[CH:15]=3)=[CH:12][C:11]([C:22]([OH:24])=O)=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].C(N(CC)C(C)C)(C)C.ClC1C=C(N2C(C3C=CC=C(OCCO)C=3)=CC(C([N:58]3[CH2:62][C:61](=[O:63])[NH:60][CH2:59]3)=O)=N2)C=CC=1>C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([F:21])[CH:15]=3)=[CH:12][C:11]([C:22]([N:58]3[CH2:62][C:61](=[O:63])[NH:60][CH2:59]3)=[O:24])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 58277347HCID 58277347, compoundHCID 58277360HCID 58277360, compound

Product 1

HCID 44230321HCID 44230321, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 106A using 3.2 equivalents of N,N-diisopropylethylamine and with the addition of 0.1% formic acid in the preparative HPLC in analogy to the synthesis of the compound of Example 23. 5 mg (6% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-5cc0e7ed69f24007aa13ceb7a58975d3
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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