Diisopropylethylamine → HCID 58277459, compound

HRID 1949323Notes

Reaction equation

HRID 1949323 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[C:15]([C:20]#[N:21])[CH:14]=3)[N:11]=[C:10]([C:22](O)=[O:23])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C(N(CC)C(C)C)(C)C.ClC1C=C(N2C(C3C=CC=C(OCCO)C=3)=CC(C([N:58]3[CH2:62][C:61](=[O:63])[NH:60][CH2:59]3)=O)=N2)C=CC=1>C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[C:15]([C:20]#[N:21])[CH:14]=3)[N:11]=[C:10]([C:22]([N:58]3[CH2:62][C:61](=[O:63])[NH:60][CH2:59]3)=[O:23])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 58277309HCID 58277309, compoundHCID 58277360HCID 58277360, compound

Product 1

HCID 58277459HCID 58277459, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 109A using 3.2 equivalents of N,N-diisopropylethylamine and with the addition of 0.1% formic acid in the preparative HPLC in analogy to the synthesis of the compound of Example 23. 45 mg (77% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-0482ae3492304eb0b403bd1048a598e2
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

Loading…