Ammonia → HCID 67153333, compound

HRID 1949325Notes

Reaction equation

HRID 1949325 reaction equation
CS(OCCCOC1C=CC=C(C2N(C3C=CC=C(Cl)C=3)N=C(C(N3CC(=O)NC3)=O)C=2)C=1)(=O)=O.N.[CH:37]([OH:39])=[O:38].C(O)=O.[Cl:43][C:44]1[CH:45]=[C:46]([N:50]2[C:54]([C:55]3[CH:60]=[CH:59][CH:58]=[C:57]([O:61][CH2:62][CH2:63][CH2:64][N:65](C)C)[CH:56]=3)=[CH:53][C:52]([C:68]([N:70]3[CH2:74][C:73](=[O:75])[NH:72][CH2:71]3)=[O:69])=[N:51]2)[CH:47]=[CH:48][CH:49]=1>CO>[CH:37]([OH:39])=[O:38].[NH2:65][CH2:64][CH2:63][CH2:62][O:61][C:57]1[CH:56]=[C:55]([C:54]2[N:50]([C:46]3[CH:47]=[CH:48][CH:49]=[C:44]([Cl:43])[CH:45]=3)[N:51]=[C:52]([C:68]([N:70]3[CH2:74][C:73](=[O:75])[NH:72][CH2:71]3)=[O:69])[CH:53]=2)[CH:60]=[CH:59][CH:58]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 284Formic AcidHCID 58277334HCID 58277334, compoundHCID 67153505HCID 67153505, compound

Product 1

HCID 67153333HCID 67153333, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 120A and a 7N solution of ammonia in methanol with the addition of 0.1% formic acid in the preparative HPLC in analogy to the synthesis of the compound of Example 29. 10 mg (10% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-e7533b44bfac43c6b60b5a574d4d8e86
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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