Diisopropylethylamine → HCID 44230251, compound

HRID 1949329Notes

Reaction equation

HRID 1949329 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[C:16]([C:21]#[N:22])[CH:15]=3)[N:12]=[C:11]([C:23](O)=[O:24])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.C(N(CC)C(C)C)(C)C.ClC1C=C(N2C(C3C=CC=C(OCCO)C=3)=CC(C([N:59]3[CH2:63][C:62](=[O:64])[NH:61][CH2:60]3)=O)=N2)C=CC=1>C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[C:16]([C:21]#[N:22])[CH:15]=3)[N:12]=[C:11]([C:23]([N:59]3[CH2:63][C:62](=[O:64])[NH:61][CH2:60]3)=[O:24])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 58277351HCID 58277351, compoundHCID 58277360HCID 58277360, compound

Product 1

HCID 44230251HCID 44230251, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 114A using 3.2 equivalents of N,N-diisopropylethylamine and with the addition of 0.1% formic acid in the preparative HPLC in analogy to the synthesis of the compound of Example 23. 44 mg (48% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-5871504020dd497aa0dea3c83ea88939
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

Loading…