4-Fluoro-2-(trifluoromethyl)benzaldehyde → HCID 81647511, compound

HRID 1949352Notes

Reaction equation

HRID 1949352 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[CH3:14][S-:15].[Na+]>CN(C=O)C>[CH3:14][S:15][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1

Participants

4

Reactant 2

HCID 5229404-Fluoro-2-(trifluoromethyl)benzaldehydeHCID 4378561Sodium methanethiolate

Product 1

HCID 81647511HCID 81647511, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

To a DMF solution (5 mL) containing 935.3 mg (4.87 mmol) of 4-fluoro-2-(trifluoromethyl)benzaldehyde was added sodium thiomethoxide (414.2 mg, 5.84 mmol). The mixture was stirred at 90° C. for 2 h, partitioned between EtOAc and water. The EtOAc extracts were washed with brine, dried over Na2SO4 and evaporated to afford desired product.

Workup

  1. custompartitioned between EtOAc and water
  2. washThe EtOAc extracts were washed with brine
  3. dry with materialdried over Na2SO4
  4. customevaporated

Sources & evidence

ORD record
ord-4fedb3ee8acc4ebaa7e0cd0bc104ebd8
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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