Cyclopropylboronic acid → HCID 67241545, compound

HRID 1949372Notes

Reaction equation

Br[C:2]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([CH:14]=[C:15]3[S:19][C:18]([N:20]4[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]4)=[N:17][C:16]3=[O:27])=[CH:11][CH:12]=2)[CH:7]=[N:6]1.[CH:36]1(B(O)O)[CH2:38][CH2:37]1>>[CH:36]1([C:2]2[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:3]=2[CH2:4][N:5]2[C:13]3[C:8](=[CH:9][C:10]([CH:14]=[C:15]4[S:19][C:18]([N:20]5[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]5)=[N:17][C:16]4=[O:27])=[CH:11][CH:12]=3)[CH:7]=[N:6]2)[CH2:38][CH2:37]1

Participants

Reactant 2

HCID 2760897Cyclopropylboronic acid

HCID 67240582HCID 67240582, compound

Product 1

HCID 67241545HCID 67241545, compound

Procedure

5-[1-(2-Cyclopropyl-4-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(4-methyl-piperazin-1-yl)-thiazol-4-one was prepared from 5-[1-(2-bromo-4-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(4-methyl-piperazin-1-yl)-thiazol-4-one and cyclopropyl boronic acid following General Procedure G.

Sources & evidence

ORD record: ord-e7e58096234e43898dcfe6142a8791c8
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399681B2

Reaction notes

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