Cyclopropylboronic acid → HCID 67241692, compound

HRID 1949374Notes

Reaction equation

Br[C:2]1[CH:33]=[CH:32][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:22]5[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][OH:30])[CH2:24][CH2:23]5)=[N:19][C:18]4=[O:31])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:34]([F:37])([F:36])[F:35])[CH:3]=1.[CH:38]1(B(O)O)[CH2:40][CH2:39]1>>[CH:38]1([C:2]2[CH:33]=[CH:32][C:5]([CH2:6][N:7]3[C:15]4[C:10](=[CH:11][C:12]([CH:16]=[C:17]5[S:21][C:20]([N:22]6[CH2:23][CH2:24][N:25]([CH2:28][CH2:29][OH:30])[CH2:26][CH2:27]6)=[N:19][C:18]5=[O:31])=[CH:13][CH:14]=4)[CH:9]=[N:8]3)=[C:4]([C:34]([F:35])([F:37])[F:36])[CH:3]=2)[CH2:40][CH2:39]1

Participants

Reactant 2

HCID 2760897Cyclopropylboronic acid

HCID 67241033HCID 67241033, compound

Product 1

HCID 67241692HCID 67241692, compound

Procedure

5-[1-(4-Cyclopropyl-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[4-(2-hydroxy-ethyl)piperazin-1-yl]-thiazol-4-one was prepared from 5-[1-(4-bromo-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-thiazol-4-one and cyclopropyl boronic acid following General Procedure F.

Sources & evidence

ORD record: ord-f0d2bb47be9342b2bbd2e5221506ba68
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399681B2

Reaction notes

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