(2R)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid → HCID 86654559, compound

HRID 1949388Notes

Reaction equation

HRID 1949388 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19](SC)=[N:18][C:17]3=[O:23])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[C:34]([O:38][C:39]([N:41]1[CH2:46][CH2:45][NH:44][C@@H:43]([C:47]([OH:49])=[O:48])[CH2:42]1)=[O:40])([CH3:37])([CH3:36])[CH3:35]>>[C:34]([O:38][C:39]([N:41]1[CH2:46][CH2:45][N:44]([C:19]2[S:20][C:16](=[CH:15][C:11]3[CH:10]=[C:9]4[C:14](=[CH:13][CH:12]=3)[N:6]([CH2:5][C:4]3[CH:24]=[CH:25][C:26]([C:28]([F:31])([F:29])[F:30])=[CH:27][C:3]=3[C:2]([F:32])([F:33])[F:1])[N:7]=[CH:8]4)[C:17](=[O:23])[N:18]=2)[CH:43]([C:47]([OH:49])=[O:48])[CH2:42]1)=[O:40])([CH3:37])([CH3:35])[CH3:36].[F:32][C:2]([F:33])([F:1])[C:3]1[CH:27]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19]([N:44]4[CH2:45][CH2:46][NH:41][CH2:42][C@@H:43]4[C:47]([OH:49])=[O:48])=[N:18][C:17]3=[O:23])=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

4

Reactant 2

HCID 6558430(2R)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acidHCID 866545435-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]2-methylsulfanyl-thiazol-4-one

Product 2

HCID 86654559HCID 86654559, compoundHCID 86654560HCID 86654560, compound

Procedure

4-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester was prepared from 5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and piperazine-1,3-(R)-dicarboxylic acid 1-tert-butyl ester following General Procedure C. Compound was not isolated and 1-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperazine-2-(R)-carboxylic acid was prepared following General Procedure H.

Workup

  1. customCompound was not isolated

Sources & evidence

ORD record
ord-1b9a56b07ff443d6bb9d82f6406d90e1
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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