HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid → HCID 86654559, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid | HCID 6558430 | — |
| Reactant | 5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]2-methylsulfanyl-thiazol-4-one | HCID 86654543 | — |
| Product | HCID 86654559 | HCID 86654559 | — |
| Product | HCID 86654560 | HCID 86654560 | — |
Reaction Steps
4-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester was prepared from 5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and piperazine-1,3-(R)-dicarboxylic acid 1-tert-butyl ester following General Procedure C. Compound was not isolated and 1-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperazine-2-(R)-carboxylic acid was prepared following General Procedure H.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399681B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-1b9a56b07ff443d6bb9d82f6406d90e1 |
| Source note | uspto-grants-2013_03 |