4-Piperidinecarboxylic acid → 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid

HRID 1949502ノート

反応式

HRID 1949502 の反応式
CS[C:3]1[S:4][CH2:5][C:6](=[O:8])[N:7]=1.[NH:9]1[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1>CO>[O:8]=[C:6]1[CH2:5][S:4][C:3]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)=[N:7]1

参加物

4

反応物 2

HCID 37734-Piperidinecarboxylic acidHCID 14820222-(Methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one

生成物 1

HCID 672406401-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-methylsulfanyl-thiazol-4-one (4.4 g, 30 mmol) in MeOH (60 mL) was added piperidine-4-carboxylic acid (3.9 g, 30 mmol). The mixture was stirred at room temperature for 16 hours. The resulting solid was collected by filtration and washed with fresh MeOH.

後処理

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with fresh MeOH

出典と根拠

ORDレコード
ord-53438912792b45f5a9eac294a2c8ba44
出典データセット
uspto-grants-2013_03
特許番号
US08399681B2

反応ノート

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