HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinecarboxylic acid → 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Reactant | 2-(Methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one | HCID 1482022 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid | HCID 67240640 | — |
Reaction Steps
To a solution of 2-methylsulfanyl-thiazol-4-one (4.4 g, 30 mmol) in MeOH (60 mL) was added piperidine-4-carboxylic acid (3.9 g, 30 mmol). The mixture was stirred at room temperature for 16 hours. The resulting solid was collected by filtration and washed with fresh MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399681B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-53438912792b45f5a9eac294a2c8ba44 |
| Source note | uspto-grants-2013_03 |