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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1949540Generated: October 30, 2026

Trifluoroacetic acid → rel-(2R,6S)-4-(3-Azetidinyl)-2,6-dimethylmorpholine

https://huagongshe.com/reaction/1949540

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 67239383HCID 67239383—
Productrel-(2R,6S)-4-(3-Azetidinyl)-2,6-dimethylmorpholineHCID 66592027—

Reaction Steps

4-Azetidin-3-yl-2,6-(cis)-dimethyl-morpholine was prepared as a TFA salt from 3-(2,6-(cis)-Dimethyl-morpholin-4-yl)-azetidine-1-carboxylic acid tert-butyl ester following General Procedure H.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08399681B2
Source datasetuspto-grants-2013_03
ORD IDord-27b4b1a6421a4576a8aa101e7cb38947
Source noteuspto-grants-2013_03