Trifluoroacetic acid → rel-(2R,6S)-4-(3-Azetidinyl)-2,6-dimethylmorpholine

HRID 1949540Notes

Reaction equation

HRID 1949540 reaction equation
C(O)(C(F)(F)F)=O.C(OC([N:15]1[CH2:18][CH:17]([N:19]2[CH2:24][C@H:23]([CH3:25])[O:22][C@H:21]([CH3:26])[CH2:20]2)[CH2:16]1)=O)(C)(C)C>>[NH:15]1[CH2:18][CH:17]([N:19]2[CH2:24][C@H:23]([CH3:25])[O:22][C@H:21]([CH3:26])[CH2:20]2)[CH2:16]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67239383HCID 67239383, compound

Product 1

HCID 66592027rel-(2R,6S)-4-(3-Azetidinyl)-2,6-dimethylmorpholine

Procedure

4-Azetidin-3-yl-2,6-(cis)-dimethyl-morpholine was prepared as a TFA salt from 3-(2,6-(cis)-Dimethyl-morpholin-4-yl)-azetidine-1-carboxylic acid tert-butyl ester following General Procedure H.

Sources & evidence

ORD record
ord-27b4b1a6421a4576a8aa101e7cb38947
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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