反应详情

A solution of 5-{1-[4-(1-Hydroxy-1-methyl-ethyl)-2-trifluoromethyl-benzyl]-1H-indazol-5-ylmethylene}-2-(2-hydroxymethyl-morpholin-4-yl)-thiazol-4-one (400 mg, 0.71 mmol) in dichloromethane (2 mL) was treated with TFA (2 mL). The reaction mixture was stirred at room temperature for 1.5 hour and partitioned between water and dichloromethane. The dichloromethane layer was washed with aqueous saturated sodium carbonate, brine, dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield a crude solid. The crude solid was purified via flash chromatography (90% ethyl acetate in Heptane) to yield the title compound as a solid (94 mg, 24% yield).

1. custompartitioned between water and dichloromethane
2. washThe dichloromethane layer was washed with aqueous saturated sodium carbonate, brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customthe solvent evaporated in vacuo
6. customto yield a crude solid
7. customThe crude solid was purified via flash chromatography (90% ethyl acetate in Heptane)