反应详情

To a solution containing 49 (200 mg, 0.41 mmol) in DCM (5 mL) was added Ac2O (65 mg, 0.63 mmol) and DMAP (5 mg, cat.) at ambient temperature. After 16 h, the reaction mixture was diluted with DCM, washed successively with 1M HCl and brine, dried over anhydrous Na2SO4, filtered, and concentrated to afford 170 mg (78%) of crude 68 which was used without further purification. Mass spectrum, m/z [527] (M+H)+.

1. washwashed successively with 1M HCl and brine
2. dry with materialdried over anhydrous Na2SO4
3. filtrationfiltered
4. concentrationconcentrated
5. customto afford 170 mg (78%) of crude 68 which
6. customwas used without further purification