Dimethylformamide dimethyl acetal → HCID 178484333, compound

HRID 1949934Notes

Reaction equation

HRID 1949934 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:12][N:13]([CH:15](OC)OC)[CH3:14]>>[CH3:12][N:13]([CH3:15])/[CH:14]=[N:6]/[C:4](=[O:5])[C:3]1[CH:7]=[CH:8][C:9]([F:11])=[CH:10][C:2]=1[F:1]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 1235882,4-Difluorobenzamide

Product 1

HCID 178484333HCID 178484333, compoundYield 91%

Conditions

Temperature
120 °C

Procedure

A suspension of 2,4-difluorobenzamide (5 g, 32 mmol) in DMF-DMA (10 mL) was heated at 120° C. for 2.5 h, allowed to cool down to RT and filtered to afford the title compound as a white solid (6.16 g, 91%). 1H NMR (CDCl3): 8.60 (1 H, s), 8.19-8.12 (1 H, m), 6.91-6.79 (2 H, m), 3.19 (6 H, m).

Workup

  1. temperatureto cool down to RT
  2. filtrationfiltered

Sources & evidence

ORD record
ord-74422dc60a8e47318ac8376789784bee
Source dataset
uspto-grants-2013_03
Patent number
US08399690B2

Reaction notes

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