4-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrile → Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

HRID 1949999Notes

Reaction equation

HRID 1949999 reaction equation
NC(C)(C)C[O:4]C1C=CC(C#N)=CC=1F.[C:16]([O:20][C:21](=[O:37])[NH:22][C:23]([CH3:36])([CH3:35])[CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]#N)=[CH:28][C:27]=1[F:34])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21](=[O:37])[NH:22][C:23]([CH3:36])([CH3:35])[CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([CH:32]=[O:4])=[CH:28][C:27]=1[F:34])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 230872344-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrileHCID 86605237Tert-butyl [2-(4-cyano-2-fluorophenoxy)-1,1-dimethylethyl]carbamate

Product 1

HCID 57934591Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

Procedure

Synthesized from 4-(2-amino-2-methylpropoxy)-3-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 19, tert-butyl[2-(4-cyano-2-fluorophenoxy)-1,1-dimethylethyl]carbamate (1.0 g) was used according to an analogous synthetic method to Preparation Example 20 to provide the title compound (715 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 20

Sources & evidence

ORD record
ord-f4e3d75a04574e4ba61a45bf727d7932
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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