Propargyl bromide → 1-(Prop-2-yn-1-yl)piperidine

HRID 1950004Notes

Reaction equation

HRID 1950004 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:7](Br)[C:8]#[CH:9]>C(OCC)C>[CH2:9]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[C:8]#[CH:7]

Participants

4

Reactant 2

HCID 7842Propargyl bromideHCID 8082Piperidine

Product 1

HCID 3366521-(Prop-2-yn-1-yl)piperidine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of piperidine (8.5 ml) in diethyl ether (100 ml) was added propargyl bromide (3 ml) on an ice bath, the solution was stirred overnight at room temperature, then diethyl ether was added thereto followed by filtering, and the solvent was evaporated in vacuo to provide the title compound (6.0 g).

Workup

  1. filtrationby filtering
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-e7c2dba4ab484d60b73b60822f9add96
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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