反应详情

A mixture of N-(2-bromo-5-methoxyphenyl)-3-fluoro-4-(2-piperidin-1-ylethoxy)benzamide (1.0 g), dichlorobis(triphenylphosphine)palladium(II) (150 mg), xylene (30 ml) and 2-tributylstannylbenzothiazole (1.9 g) was refluxed for 2 hours. The reaction mixture was concentrated in vacuo and the resulting residue was purified by NH silica gel column chromatography (hexane-ethyl acetate system) to provide the title compound (810 mg).

1. temperaturewas refluxed for 2 hours
2. concentrationThe reaction mixture was concentrated in vacuo
3. customthe resulting residue was purified by NH silica gel column chromatography (hexane-ethyl acetate system)