6-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate → 7-Methoxy-3-(4-methoxy-2-nitrophenyl)-1,2-dihydronaphthalene

HRID 1950048Notes

Reaction equation

HRID 1950048 reaction equation
FC(F)(F)S(O[C:7]1[CH2:16][CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=2)[CH:8]=1)(=O)=O.C([Sn](CCCC)(CCCC)[C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=1[N+:34]([O-:36])=[O:35])CCC>>[CH3:18][O:17][C:12]1[CH:13]=[C:14]2[C:9]([CH:8]=[C:7]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=3[N+:34]([O-:36])=[O:35])[CH2:16][CH2:15]2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 153302566-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonateHCID 23087474Tributyl(4-methoxy-2-nitrophenyl)tin

Product 1

HCID 230871417-Methoxy-3-(4-methoxy-2-nitrophenyl)-1,2-dihydronaphthaleneYield 73.2%

Procedure

Synthesized from 6-methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate (2.3 g) and tributyl(4-methoxy-2-nitrophenyl)tin (3.9 g) according to an analogous synthetic method to Preparation Example 77, the title compound (1.7 g) was obtained.

Workup

  1. customaccording to an analogous synthetic method to Preparation Example 77

Sources & evidence

ORD record
ord-abad95a7466a44ad9de9febe7ddd41a6
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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