4-Bromo-3-nitroanisole → 5-Methoxy-2-(6-methoxy-3,3-dimethyl-3,4-dihydronaphthalen-2-yl)phenylamine

HRID 1950086Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1950086
BrC1C(C)(C)CC2C(C=1)=CC=C(OC)C=2.BrC1C=CC(OC)=CC=1[N+]([O-])=O.[CH3:28][O:29][C:30]1[CH:39]=[C:38]2[C:33]([CH:34]=[C:35]([C:42]3[CH:47]=[CH:46][C:45]([O:48][CH3:49])=[CH:44][C:43]=3[N+:50]([O-])=O)[C:36]([CH3:41])([CH3:40])[CH2:37]2)=[CH:32][CH:31]=1>>[CH3:49][O:48][C:45]1[CH:46]=[CH:47][C:42]([C:35]2[C:36]([CH3:40])([CH3:41])[CH2:37][C:38]3[C:33](=[CH:32][CH:31]=[C:30]([O:29][CH3:28])[CH:39]=3)[CH:34]=2)=[C:43]([NH2:50])[CH:44]=1

Komponenten

4

Edukt 3

HCID 792884-Bromo-3-nitroanisoleHCID 230874327-Methoxy-3-(4-methoxy-2-nitrophenyl)-2,2-dimethyl-1,2-dihydronaphthaleneHCID 230875703-Bromo-7-methoxy-2,2-dimethyl-1,2-dihydronaphthalene

Produkt 1

HCID 230873205-Methoxy-2-(6-methoxy-3,3-dimethyl-3,4-dihydronaphthalen-2-yl)phenylamineAusbeute 75,1 %

Versuchsvorschrift

Synthesized from 3-bromo-7-methoxy-2,2-dimethyl-1,2-dihydronaphthalene and 4-bromo-3-nitroanisole according to an analogous synthetic method to Preparation Example 107 described below, 7-methoxy-3-(4-methoxy-2-nitrophenyl)-2,2-dimethyl-1,2-dihydronaphthalene (1.9 g) was used according to an analogous synthetic method to Example 57 to provide the title compound (1.3 g).

Quellen und Nachweise

ORD-Eintrag
ord-36cec00b0b904a60890b7136475fad9b
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399520B2

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