Propionic anhydride → 6-(4-Methoxy-2-propylaminophenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 1950113Notes

Reaction equation

HRID 1950113 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]1[CH2:19][CH2:18][C:17]2[CH:16]=[C:15]([OH:20])[CH:14]=[CH:13][C:12]=2[CH2:11]1.[C:21](OC(=O)CC)(=O)[CH2:22][CH3:23]>>[CH3:9][O:8][C:6]1[CH:5]=[CH:4][C:3]([CH:10]2[CH2:19][CH2:18][C:17]3[CH:16]=[C:15]([OH:20])[CH:14]=[CH:13][C:12]=3[CH2:11]2)=[C:2]([NH:1][CH2:21][CH2:22][CH3:23])[CH:7]=1

Participants

3

Reactant 2

HCID 31263Propionic anhydrideHCID 230873286-(2-Amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

Product 1

HCID 230871756-(4-Methoxy-2-propylaminophenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

Procedure

Synthesized from 6-(2-amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol (500 mg) and propionic anhydride (1 ml) according to an analogous synthetic method to Example 36, the title compound (270 mg) was obtained.

Sources & evidence

ORD record
ord-b3b025dcae734d008138f81891887a92
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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