反应详情

温度

60 °C

To a solution of 5-{4-hydroxy-2-[4-(2-piperidin-1-ylethoxy)phenylamino]phenyl}indan-1-one (28 mg) in ethanol (1 ml) and tetrahydrofuran (0.2 ml) were sequentially added hydroxylammonium chloride (43 mg) and pyridine (0.2 ml), and the solution was stirred overnight at 60° C. Water was added thereto followed by stirring, the solution was extracted with ethyl acetate, then sequentially washed with water and brine, and the solvent was evaporated in vacuo. The residue was purified by NH silica gel column chromatography (ethyl acetate-methanol system) to provide the title compound (6 mg).

1. stirringby stirring
2. extractionthe solution was extracted with ethyl acetate
3. washsequentially washed with water and brine
4. customthe solvent was evaporated in vacuo
5. customThe residue was purified by NH silica gel column chromatography (ethyl acetate-methanol system)