Dichloromethane → HCID 23087516, compound

HRID 1950316Notes

Reaction equation

HRID 1950316 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][N:6]([CH3:14])[C:7](=O)[O:8]C(C)(C)C)[CH3:2].FC(F)(F)C(O)=O.[Cl:22][CH2:23]Cl>>[Cl:22][CH2:23][C:7]([N:6]([CH2:5][CH2:4][O:3][CH2:1][CH3:2])[CH3:14])=[O:8]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57934553HCID 57934553, compound

Product 1

HCID 23087516HCID 23087516, compound

Procedure

To a solution of tert-butyl (2-ethoxyethyl)methylcarbamate (1.2 g) in dichloromethane (6 ml) was added trifluoroacetic acid (6 ml) on an ice bath. The solution was stirred for 30 minutes while warming to room temperature, then the solvent was evaporated in vacuo. Synthesized from the resulting (2-ethoxyethyl)methylamine trifluoroacetate (crude product) (2.3 g) according to an analogous synthetic method to Preparation Example 119, the title compound (799 mg) was obtained.

Workup

  1. customthe solvent was evaporated in vacuo
  2. customSynthesized from the resulting (2-ethoxyethyl)methylamine trifluoroacetate (crude product) (2.3 g)
  3. customaccording to an analogous synthetic method to Preparation Example 119

Sources & evidence

ORD record
ord-b5c9d4e6f7c545ef932cd32d83606ebc
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

Loading…