1,3-Dimethoxybenzene → 1-(2,4-Dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

HRID 1950619Notes

Reaction equation

HRID 1950619 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[CH:4]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20](Cl)=[O:21])=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][CH3:10])[CH:6]=[CH:7][C:8]=1[C:20](=[O:21])[CH2:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 90251,3-DimethoxybenzeneHCID 27346884-Methoxyphenylacetyl chloride

Product 1

HCID 134271631-(2,4-Dimethoxyphenyl)-2-(4-methoxyphenyl)ethanoneYield 51.6%

Procedure

Synthesized from 1,3-dimethoxybenzene (8.2 g) and 4-methoxyphenylacetyl chloride (10.0 g) according to an analogous synthetic method to Preparation Example 66, the title compound (8.0 g) was obtained.

Workup

  1. customaccording to an analogous synthetic method to Preparation Example 66

Sources & evidence

ORD record
ord-7c4ec359f6f74e8c98cad45bbe85a692
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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