HCID 57934253, compound → HCID 57934339, compound

HRID 1950647Notes

Reaction equation

HRID 1950647 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].C(OC([CH2:36][NH:37][C:38]([CH3:50])([CH3:49])[CH2:39][C:40]1[CH:48]=[CH:47][C:43]([C:44](O)=O)=[CH:42][CH:41]=1)=O)(C)(C)C.C(OC(CNC(C)(C)CC1C=CC(C(CCNC2C=C(OC)C=CC=2C2CCC3C=C(OC(=O)C(C)(C)C)C=CC=3C2)=O)=CC=1)=O)(C)(C)C>>[CH2:1]([N:3]([CH2:44][C:43]1[CH:47]=[CH:48][C:40]([CH2:39][C:38]([CH3:50])([NH:37][CH3:36])[CH3:49])=[CH:41][CH:42]=1)[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2]

Participants

4

Reactant 3

HCID 57934253HCID 57934253, compoundHCID 66627623HCID 66627623, compoundHCID 66627950HCID 66627950, compound

Product 1

HCID 57934339HCID 57934339, compoundYield 38.7%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (100 mg) and 4-[2-(tert-butoxycarbonylmethylamino)-2-methylpropyl]benzoic acid (120 mg) according to an analogous synthetic method to Preparation Example 86, pivalic acid 6-{2-{{4-[2-(tert-butoxycarbonylmethylamino)-2-methylpropyl]benzoyl}ethylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (97 mg) was used according to analogous synthetic method to the above-mentioned Example 215 and Example 337 to provide the title compound (48 mg).

Sources & evidence

ORD record
ord-4e36f3dd76784868a70ecb4df861bf38
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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