反应详情

温度

135 °C

The alkyl anisole of Example 1 (40 g) was transferred to a dry 3-neck 1-litre flask under nitrogen. To this was added tributylhexadecylphosphonium bromide (12.69 g) and HBr (48% aq., 71.4 ml). The resulting thick suspension was warmed to 135° C. and stirred for five hours. Toluene was added and the reaction was transferred to a separating funnel. The organic layer was shaken with water and then the aqueous extract shaken with fresh toluene. The organic extracts were combined and dried with MgSO4. The solvent was removed in vacuo to give the title compound as a brown solid.

1. customthe reaction was transferred to a separating funnel
2. extractionthe aqueous extract
3. stirringshaken with fresh toluene
4. dry with materialdried with MgSO4
5. customThe solvent was removed in vacuo