Succinic anhydride → HCID 58482662, compound

HRID 1950738Notes

Reaction equation

HRID 1950738 reaction equation
[C:1]([O:5][C:6]([NH:8][N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][OH:17])[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:18]1(=[O:24])[O:23][C:21](=[O:22])[CH2:20][CH2:19]1>CN(C1C=CN=CC=1)C.C(Cl)(Cl)Cl>[C:1]([O:5][C:6]([NH:8][N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][O:17][C:18](=[O:24])[CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH2:13][CH2:14]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 7922Succinic anhydrideHCID 58482717HCID 58482717, compound

Product 1

HCID 58482662HCID 58482662, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6212ChloroformSolvent

Procedure

Compound 4 (250 mg, 1.0 mmol), succinic anhydride (105 mg, 1.05 mmol) and 4-DMAP (cat.) were dissolved in CHCl3 (600 μL) and stirred for 12 hours. The solution was concentrated in vacuo and used without further purification. 1H NMR (400 MHz, CDCl3) δ 1.43 (s, 9H), 2.60 (s, 4H), 2.76 (m, 6H), 2.86 (m, 4H), 4.23 (t, J=5.5 Hz, 2H), 5.71 (br s, 1H), 10.82 (br s, 1H).

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customused without further purification

Sources & evidence

ORD record
ord-c23566c9647d4e45b2172de7a4f1b8ed
Source dataset
uspto-grants-2013_03
Patent number
US08404664B2

Reaction notes

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