HuagongsheHuagongshe Chemistry Print Report · For research reference only
Succinic anhydride → 1-(t-Butyloxycarbonyl)-4-(2-(4-hydroxy-4-oxo-butanoyloxy)ethyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate | HCID 735736 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-(t-Butyloxycarbonyl)-4-(2-(4-hydroxy-4-oxo-butanoyloxy)ethyl)piperazine | HCID 58482577 | — |
Reaction Steps
Compound 57 (5.3 g, 23.0 mmol), succinic anhydride (2.30 g, 23.0 mmol) and 4-dimethylaminopyridine (281 mg, 2.30 mmol) were dissolved in CHCl3 (14 mL) and stirred for 18 h. The solution was concentrated in vacuo and used without further purification. 1H NMR (400 MHz, CDCl3) δ 1.42 (s, 9H), 2.54-2.60 (m, 8H), 2.72 (t, J=5.6, 2H), 3.43-3.46 (m, 4H), 4.23 (t, J=5.5, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404664B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d77c103601de4ddf90359c282e5ccddf |
| Source note | uspto-grants-2013_03 |