関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium bisulfate | HCID 516920 | — |
| 反応物 | (1-Ethoxycyclopropoxy)trimethylsilane | HCID 2734686 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 4-(4-Nitrophenyl)piperidine | HCID 15925817 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-Cyclopropyl-4-(4-nitrophenyl)piperidine | HCID 68672156 | — |
反応手順
0.50 g 4-(4-nitro-phenyl)-piperidine are dissolved in 1.5 mL methanol and combined with 0.80 g sodium cyanoborohydride and 2 μL glacial acetic acid. Then 0.97 mL [(1-ethoxycyclopropyl)oxy]trimethylsilane are added and the mixture is stirred for 24 h at 50° C. After cooling, 100 mL potassium hydrogen sulphate solution (10%) are added and the mixture is extracted twice with dichloromethane. The combined organic phases are dried, the solvent is eliminated in vacuo. The residue is used in the next stage of the synthesis without any further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08404674B2 |
|---|
| 出典データセット | uspto-grants-2013_03 |
|---|
| ORD ID | ord-935bd007b6c24c569df057e26ee60d6c |
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| 出典メモ | uspto-grants-2013_03 |
|---|
