反应详情

温度

50 °C

0.50 g 4-(4-nitro-phenyl)-piperidine are dissolved in 1.5 mL methanol and combined with 0.80 g sodium cyanoborohydride and 2 μL glacial acetic acid. Then 0.97 mL [(1-ethoxycyclopropyl)oxy]trimethylsilane are added and the mixture is stirred for 24 h at 50° C. After cooling, 100 mL potassium hydrogen sulphate solution (10%) are added and the mixture is extracted twice with dichloromethane. The combined organic phases are dried, the solvent is eliminated in vacuo. The residue is used in the next stage of the synthesis without any further purification.

1. temperatureAfter cooling
2. extractionthe mixture is extracted twice with dichloromethane
3. customThe combined organic phases are dried
4. customThe residue is used in the next stage of the synthesis without any further purification