HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopropyl-4-(4-nitrophenyl)piperidine → 4-(1-Cyclopropylpiperidin-4-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopropyl-4-(4-nitrophenyl)piperidine | HCID 68672156 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(1-Cyclopropylpiperidin-4-yl)aniline | HCID 68672941 | — |
Reaction Steps
0.57 g 1-cyclopropyl-4-(4-nitro-phenyl)-piperidine are dissolved in 30 mL tetrahydrofuran and combined with Pd/C. The mixture is hydrogenated for 72 h at 7 bar hydrogen pressure. Then the catalyst is filtered off and the solvent is eliminated in vacuo. The residue is used in the next stage of the synthesis without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404674B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-f55b8c37592e45d989c6a93a135b05a9 |
| Source note | uspto-grants-2013_03 |