1-Cyclopropyl-4-(4-nitrophenyl)piperidine → 4-(1-Cyclopropylpiperidin-4-yl)aniline

HRID 1950749Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1950749
[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]3[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=3)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.[H][H]>O1CCCC1.[Pd]>[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]3[CH:11]=[CH:12][C:13]([NH2:16])=[CH:14][CH:15]=3)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 686721561-Cyclopropyl-4-(4-nitrophenyl)piperidineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 686729414-(1-Cyclopropylpiperidin-4-yl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.57 g 1-cyclopropyl-4-(4-nitro-phenyl)-piperidine are dissolved in 30 mL tetrahydrofuran and combined with Pd/C. The mixture is hydrogenated for 72 h at 7 bar hydrogen pressure. Then the catalyst is filtered off and the solvent is eliminated in vacuo. The residue is used in the next stage of the synthesis without any further purification.

Aufarbeitung

  1. filtrationThen the catalyst is filtered off
  2. customThe residue is used in the next stage of the synthesis without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-f55b8c37592e45d989c6a93a135b05a9
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08404674B2

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