Nitroethane → (3aS,6aS)-rel-3-methyl-3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazole

HRID 1950760Notes

Reaction equation

[N+:1]([CH2:4][CH3:5])([O-])=[O:2].[O:6]1[CH2:10][CH:9]=[CH:8][CH2:7]1>>[CH3:5][C:4]1[C@H:8]2[CH2:7][O:6][CH2:10][C@H:9]2[O:2][N:1]=1

Participants

Reactant 2

HCID 6587Nitroethane

HCID 155702,5-Dihydrofuran

Product 1

HCID 68159032(3aS,6aS)-rel-3-methyl-3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazole

Procedure

Intermediate IV-1: Starting from nitroethane and 2,5-dihydro-furan, the product (3aS,6aS)-rel-3-methyl-3a,4,6,6a-tetrahydro-furo[3,4-d]isoxazole was obtained as a pale yellow solid.

Sources & evidence

ORD record: ord-485ca504d0ab4f628af6824fd25658f9
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404680B2

Reaction notes

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