Piperidin-4-ol → HCID 58494270, compound

HRID 1950783Notes

Reaction equation

HRID 1950783 reaction equation
CS[C:3]1[N:4]=[C:5]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[C:6]2[C:12](=[O:13])[NH:11][CH:10]=[CH:9][C:7]=2[N:8]=1.[OH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[OH:25][CH:26]1[CH2:31][CH2:30][N:29]([C:3]2[N:4]=[C:5]([NH:14][C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=3)[C:6]3[C:12](=[O:13])[NH:11][CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 58494179HCID 58494179, compound

Product 1

HCID 58494270HCID 58494270, compound

Procedure

The title compound was prepared as described in Example 1g by starting from 2-(methylthio)-4-(3-(trifluoromethyl)phenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one (100 mg, 0.26 mmol) and 4-hydroxypiperidine to yield the title compound (73 mg) as white solids. MS m/z: 406 (M+H)+, 1H NMR (300 MHz), δ ppm 1.21-1.35 (m, 4H), 3.76-3.78 (m, 1H), 4.26-4.28 (m, 4H), 6.17 (d, J=7.2 Hz, 1H), 7.38-7.68 (m, 4H), 7.90 (s, 1H), 8.61 (s, 1H), 11.42 (s, 1H), 12.10 (s, 1H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-14387494dae049b9bc2a29cb08273c08
Source dataset
uspto-grants-2013_03
Patent number
US08404677B2

Reaction notes

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