Hydrochloric Acid → 6-[2-(Methoxymethyl)pyrrolidin-1-yl]-5-methylnicotinic acid

Participants

Reaction Steps

A mixture of 6-[2-(methoxymethyl)pyrrolidin-1-yl]-5-methylnicotinonitrile (591 mg; 2.56 mmol; 1 eq.) and potassium hydroxide (717 mg; 12.8 mmol; 5 eq.) in water (20 mL) was stirred at reflux for 16 hours. The pH was adjusted to 5-6 with HCl 1M and the aqueous layer extracted with ethyl acetate. The combined organic phase was dried over magnesium sulphate and concentrated in vacuo to afford the title compound (0.63 g, 99%) as a white solid.

Provenance & Evidence