反应详情

A mixture of 6-[2-(methoxymethyl)pyrrolidin-1-yl]-5-methylnicotinonitrile (591 mg; 2.56 mmol; 1 eq.) and potassium hydroxide (717 mg; 12.8 mmol; 5 eq.) in water (20 mL) was stirred at reflux for 16 hours. The pH was adjusted to 5-6 with HCl 1M and the aqueous layer extracted with ethyl acetate. The combined organic phase was dried over magnesium sulphate and concentrated in vacuo to afford the title compound (0.63 g, 99%) as a white solid.

1. temperatureat reflux for 16 hours
2. extractionthe aqueous layer extracted with ethyl acetate
3. dry with materialThe combined organic phase was dried over magnesium sulphate
4. concentrationconcentrated in vacuo