2,4,6-Trimethylbenzoic acid → 2,4,6-Trimethyl-cis-N-(2-pyrrolidin-1-yl-cyclopentyl)-benzamide

HRID 1950988Notes

Reaction equation

HRID 1950988 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:12][C:13]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[C:14]=1[C:15](O)=[O:16]>>[CH3:12][C:13]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[C:14]=1[C:15]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:16]

Participants

3

Reactant 2

HCID 101942,4,6-Trimethylbenzoic acidHCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×

Product 1

HCID 666817652,4,6-Trimethyl-cis-N-(2-pyrrolidin-1-yl-cyclopentyl)-benzamide

Procedure

The title compound, white solid, MS: m/e=301.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2,4,6-trimethylbenzoic acid.

Sources & evidence

ORD record
ord-c9969799a7cd4811855fbd8473ca9f74
Source dataset
uspto-grants-2013_03
Patent number
US08404673B2

Reaction notes

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